Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 164
interventional 140
Observational 22
Registry 2

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 15
Drug|Other 14
Drug|Radiation 12
Radiation 10
Drug|Procedure|Radiation 9
Other 8
Drug|Procedure 6
Biological|Drug|Other 5
Biological|Drug|Other|Radiation 5
Device 5
Behavioral 4
Biological 4
Biological|Drug 4
Drug|Other|placebo 4
Procedure 4
Procedure|Radiation 4
Drug|Other|Procedure|Radiation 3
Behavioral|Other 2
Behavioral|Procedure|Radiation 2
Biological|Other|Radiation 2
Drug|Other|Radiation 2
Drug|placebo 2
Biological|Drug|Other|placebo|Procedure 1
Biological|Drug|Other|Procedure|Radiation 1
Biological|Drug|Radiation 1
Biological|Other 1
Biological|Other|Procedure|Radiation 1
Device|Drug|Radiation 1
Diagnostic Test 1
Dietary Supplement 1
Dietary Supplement|Other 1
Dietary Supplement|Procedure 1
Drug|Other|placebo|Radiation 1
Drug|placebo|Procedure 1
Other|placebo 1
Other|Procedure 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 99
France 7
Canada 5
China 4
Denmark 4
United Kingdom 3
Australia|Canada 2
Germany 2
India 2
United States|Canada 2
Austria 1
Belgium 1
Belgium|France|Switzerland|United Kingdom 1
Brazil 1
NA 1
Sweden 1
Switzerland 1
United States|Australia|Belgium|France|United Kingdom 1
United States|Canada|China 1
United States|Canada|Ireland|Saudi Arabia 1

Sites per Study

Site_count Study_Count
1 93
2 8
3 4
4 5
5 6
6 2
7 2
8 4
9 1
10 1
11 3
12 1
18 1
20 1
33 1
40 1
58 1
220 1
222 1
228 1
232 1
533 1

Phase

Phase Study_Count
Phase 2 57
N/A 36
Phase 1 17
Phase 1/Phase 2 14
Phase 3 8
Phase 2/Phase 3 7
Phase 4 1

Number of Arms

Number_of_Arms Count_of_Studies
1 69
2 52
3 11
4 3
5 3
NA 2

Enrollment Metrics by Phase

Measure N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 10.0000 3.00000 12.00000 9.00000 120.0000 24.000 280
1st Qu. 38.2500 13.00000 34.00000 39.00000 301.5000 126.500 280
Median 50.5000 27.00000 58.00000 66.00000 523.0000 262.000 280
Mean 119.6944 28.70588 55.23077 88.77193 482.2857 428.125 280
3rd Qu. 102.2500 41.00000 71.00000 106.00000 693.0000 731.250 280
Max. 1305.0000 75.00000 100.00000 511.00000 744.0000 1100.000 280

Trial Group Type

group_type Group_Count
Experimental 173
Active Comparator 31
No Intervention 11
Placebo Comparator 10
Other 8
NA 2

Intervention Model

intervention_model Study_Count
Single Group Assignment 71
Parallel Assignment 65
Sequential Assignment 2
Crossover Assignment 1
NA 1

Primary Purpose

primary_purpose Study_Count
Treatment 108
Diagnostic 9
Supportive Care 9
Prevention 7
Health Services Research 3
Other 3
Basic Science 1

Observational Studies

Studies by Country

Country Study_Count
United States 15
France 3
Belgium|Germany 1
Denmark 1
Germany 1
Norway 1

Sites per Study

Site_count Study_Count
1 16
2 2
4 2
14 1
28 1

Enrollment Metrics

Measure Observational
Min 20.0000
1st Qu 45.5000
Median 85.5000
Mean 264.8636
3rd Qu 249.5000
Max 1500.0000

Observation Model

observational_model Study_Count
Cohort 13
Case-Only 6
Case-Control 1
Case Control 1
Other 1

Time Perspective

time_perspective Study_Count
Prospective 18
Cross-Sectional 2
Retrospective 2

Registries

Studies by Country

Country Study_Count
United States 2

Sites per Study

Site_count Study_Count
1 1
75 1

Enrollment Metrics

Measure Registries
Min 1500.0
1st Qu 251124.8
Median 500749.5
Mean 500749.5
3rd Qu 750374.2
Max 999999.0

Registry Model

observational_model Study_Count
Cohort 2

Time Perspective

time_perspective Study_Count
Prospective 2

Follow-up

target_duration Study_Count
4 Years 1
80 Years 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT04015336 E7 TCR Cell Induction Immunotherapy for Stage II and Stage III HPV-Associated Oropharyngeal Cancer https://ClinicalTrials.gov/show/NCT04015336 Recruiting National Institutes of Health Clinical Center (CC) 2023-04-28
NCT03874572 Allogeneic Mesenchymal Stem Cells for Radiation-induced Hyposalivation and Xerostomia/Dry Mouth https://ClinicalTrials.gov/show/NCT03874572 Active, not recruiting Rigshospitalet, Denmark 2020-06-22
NCT03383094 Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer https://ClinicalTrials.gov/show/NCT03383094 Recruiting University of California, San Diego 2021-04-30
NCT03346915 Integrating a Health Information Technology System for Primary and Secondary Cervical Cancer Prevention https://ClinicalTrials.gov/show/NCT03346915 Completed Boston Medical Center 2019-04-19
NCT03822897 De-Escalation Radiotherapy in Patients With Low-Risk HPV-Related Oropharyngeal Squamous Cell Carcinoma https://ClinicalTrials.gov/show/NCT03822897 Recruiting Canadian Cancer Trials Group 2023-12-31
NCT03302676 The Use of Chewing Gum for Xerostomia and Hyposalivation After Radiotherapy for Oral and Oropharyngeal Tumors https://ClinicalTrials.gov/show/NCT03302676 Completed Odense University Hospital 2018-09-30
NCT03258008 Utomilumab and ISA101b Vaccination in Patients With HPV-16-Positive Incurable Oropharyngeal Cancer https://ClinicalTrials.gov/show/NCT03258008 Active, not recruiting M.D. Anderson Cancer Center 2021-06-30
NCT03226613 New Modalities for Detection of Oropharyngeal Cancer https://ClinicalTrials.gov/show/NCT03226613 Completed Vanderbilt University Medical Center 2018-06-06
NCT03224000 Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer https://ClinicalTrials.gov/show/NCT03224000 Recruiting M.D. Anderson Cancer Center 2025-01-31
NCT03215719 Adaptive Treatment De-escalation in Favorable Risk HPV-Positive Oropharyngeal Carcinoma https://ClinicalTrials.gov/show/NCT03215719 Recruiting NYU Langone Health 2020-04-30
NCT03210103 Primary Radiotherapy Versus Primary Surgery for HPV-Associated Oropharyngeal Cancer https://ClinicalTrials.gov/show/NCT03210103 Recruiting Lawson Health Research Institute 2028-08-15
NCT03096808 Adaptive Radiotherapy for Head and Neck Cancer https://ClinicalTrials.gov/show/NCT03096808 Active, not recruiting Memorial Sloan Kettering Cancer Center 2021-03-15
NCT03082534 Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma https://ClinicalTrials.gov/show/NCT03082534 Recruiting University of California, San Diego 2019-12-30
NCT03077243 P53 Mutational Status and cf HPV DNA for the Management of HPV-associated OPSCC https://ClinicalTrials.gov/show/NCT03077243 Recruiting UNC Lineberger Comprehensive Cancer Center 2022-08-31
NCT03074110 Isocapnic Hyperventilation - an Alternative Method https://ClinicalTrials.gov/show/NCT03074110 Completed Sahlgrenska University Hospital, Sweden 2017-08-15
NCT03049280 Prospective, Multicenter da Vinci® SP™ Surgical System TORS Study https://ClinicalTrials.gov/show/NCT03049280 Completed Intuitive Surgical 2017-11-14
NCT03010813 A Novel Robotic System for Single Port and Natural Orifice Transluminal Endoscopic Surgery https://ClinicalTrials.gov/show/NCT03010813 Completed Chinese University of Hong Kong 2017-10-31
NCT02984410 Study Assessing The “Best of” Radiotherapy vs the “Best of” Surgery in Patients With Oropharyngeal Carcinoma https://ClinicalTrials.gov/show/NCT02984410 Recruiting European Organisation for Research and Treatment of Cancer - EORTC 2020-11-30
NCT02981862 CaptHPV : Validation of the Method “CaptHPV” for the Diagnosis of Human Papillomavirus Associated Infiltrating Carcinomas https://ClinicalTrials.gov/show/NCT02981862 Completed Institut de Cancérologie de Lorraine 2018-06-12
NCT02945631 Quarterback 2b - Sequential Therapy With Reduced Dose Chemoradiotherapy for HPV Oropharynx Cancer https://ClinicalTrials.gov/show/NCT02945631 Recruiting Icahn School of Medicine at Mount Sinai 2023-04-30
NCT02908477 Evaluation of De-escalated Adjuvant Radiation Therapy for Human Papillomavirus (HPV)-Associated Oropharynx Cancer https://ClinicalTrials.gov/show/NCT02908477 Recruiting Mayo Clinic 2024-09-15
NCT02792322 A Pilot Study Assessing Robotic Surgery in the Seated Position for Benign and Malignant Lesions of the Head and Neck https://ClinicalTrials.gov/show/NCT02792322 Recruiting Mayo Clinic 2020-05-31
NCT02757222 Dose Escalation Versus Standard in Laryngopharyngeal Cancers https://ClinicalTrials.gov/show/NCT02757222 Recruiting Tata Medical Center 2020-12-31
NCT02703493 Image-Guided Stereotactic Radiosurgery (SRS) Boost for HPV-Oropharyngeal Cancer https://ClinicalTrials.gov/show/NCT02703493 Active, not recruiting Northwell Health 2020-02-01
NCT02586207 Pembrolizumab in Combination With CRT for LA-SCCHN https://ClinicalTrials.gov/show/NCT02586207 Active, not recruiting Sanford Health 2020-06-30
NCT02558803 HPV Vaccination: Evaluation of Reminder Prompts for Doses 2 & 3 https://ClinicalTrials.gov/show/NCT02558803 Completed Regenstrief Institute, Inc. 2016-05-31
NCT02551887 HPV Vaccination: An Investigation of Physician Reminders and Recommendation Scripts https://ClinicalTrials.gov/show/NCT02551887 Completed Regenstrief Institute, Inc. 2015-04-30
NCT02412241 Establishing Lymphedema and Fibrosis Measures in Oral Cancer Patients https://ClinicalTrials.gov/show/NCT02412241 Active, not recruiting Vanderbilt-Ingram Cancer Center 2020-02-29
NCT02338102 Nasal Saline Irrigation After Radiation Therapy for Oropharyngeal Cancer https://ClinicalTrials.gov/show/NCT02338102 Completed University of Kansas Medical Center 2015-05-31
NCT02281955 De-intensification of Radiation and Chemotherapy for Low-Risk HPV-related Oropharyngeal SCC: Follow-up Study https://ClinicalTrials.gov/show/NCT02281955 Active, not recruiting UNC Lineberger Comprehensive Cancer Center 2019-11-30
NCT02280811 T Cell Receptor Immunotherapy Targeting HPV-16 E6 for HPV-Associated Cancers https://ClinicalTrials.gov/show/NCT02280811 Completed National Institutes of Health Clinical Center (CC) 2016-06-28
NCT02277548 A Pilot Study at a Single-Institution of Pregabalin in the Management of Mucositis Pain in Patients Undergoing Chemoradiation Therapy to the Head and Neck. https://ClinicalTrials.gov/show/NCT02277548 Completed Abramson Cancer Center of the University of Pennsylvania 2018-04-30
NCT02258659 Nab-paclitaxel and Carboplatin Followed by Response-Based Local Therapy in Treating Patients With Stage III or IV HPV-Related Oropharyngeal Cancer https://ClinicalTrials.gov/show/NCT02258659 Active, not recruiting University of Chicago 2018-12-31
NCT02254278 Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal Cancer https://ClinicalTrials.gov/show/NCT02254278 Active, not recruiting NRG Oncology 2019-06-10
NCT02215265 Post-operative Adjuvant Treatment for HPV-positive Tumours (PATHOS) https://ClinicalTrials.gov/show/NCT02215265 Recruiting Velindre NHS Trust 2026-10-31
NCT02177838 Cetuximab and Radiation Therapy in Treating Patients With Stage III-IV Head and Neck Cancer https://ClinicalTrials.gov/show/NCT02177838 Recruiting Rutgers, The State University of New Jersey 2020-06-01
NCT02159703 A Single-arm Phase II Study of Post-Transoral Robotic Surgery (TORS) Alone to the Primary Tumor Site and Selective Neck Dissection (SND) Followed by Adjuvant Radiation Therapy (+/- Chemotherapy) to the Regional Nodes for Advanced Stage, Human Papilloma Virus (HPV) Positive, Oropharyngeal Cancer https://ClinicalTrials.gov/show/NCT02159703 Completed Abramson Cancer Center of the University of Pennsylvania 2018-02-28
NCT02123511 Acetylcysteine Rinse in Reducing Saliva Thickness and Mucositis in Patients With Head and Neck Cancer Undergoing Radiation Therapy https://ClinicalTrials.gov/show/NCT02123511 Completed Mayo Clinic 2016-03-22
NCT01316757 Carboplatin, Paclitaxel, Cetuximab, and Erlotinib Hydrochloride in Treating Patients With Metastatic or Recurrent Head and Neck Squamous Cell Cancer https://ClinicalTrials.gov/show/NCT01316757 Completed Fox Chase Cancer Center 2015-04-07
NCT02048020 Paclitaxel and Carboplatin Before Radiation Therapy With Paclitaxel in Treating HPV-Positive Patients With Stage III-IV Oropharynx, Hypopharynx, or Larynx Cancer https://ClinicalTrials.gov/show/NCT02048020 Completed Jonsson Comprehensive Cancer Center 2017-01-09
NCT02035527 Sorafenib Tosylate, Cisplatin, and Docetaxel in Treating Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck https://ClinicalTrials.gov/show/NCT02035527 Completed Ohio State University Comprehensive Cancer Center 2017-04-20
NCT03174275 Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma https://ClinicalTrials.gov/show/NCT03174275 Recruiting UNC Lineberger Comprehensive Cancer Center 2021-09-01
NCT03258554 Radiation Therapy With Durvalumab or Cetuximab in Treating Patients With Locoregionally Advanced Head and Neck Cancer Who Cannot Take Cisplatin https://ClinicalTrials.gov/show/NCT03258554 Recruiting National Cancer Institute (NCI) 2025-12-31
NCT01984359 HPV Serum DNA Levels Predicting Outcome in p16+ Squamous Cell Head and Neck Cancer https://ClinicalTrials.gov/show/NCT01984359 Completed Abramson Cancer Center of the University of Pennsylvania 2015-12-31
NCT01898494 Transoral Surgery Followed By Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer https://ClinicalTrials.gov/show/NCT01898494 Active, not recruiting Eastern Cooperative Oncology Group 2020-02-29
NCT01893307 Randomized Trial of Intensity-Modulated Proton Beam Therapy (IMPT) Versus Intensity-Modulated Photon Therapy (IMRT) for the Treatment of Oropharyngeal Cancer of the Head and Neck https://ClinicalTrials.gov/show/NCT01893307 Recruiting M.D. Anderson Cancer Center 2023-08-31
NCT01884259 Induction Chemotherapy With TP+5-FU or TP+Cetuximab Followed by Radioimmuptherapy for Locally Advanced or Not Resectable SCCHNN https://ClinicalTrials.gov/show/NCT01884259 Active, not recruiting Arbeitsgemeinschaft medikamentoese Tumortherapie 2021-01-31
NCT01874587 Adaptative Radiotherapy to Decrease Xerostomia in Oropharynx Carcinoma https://ClinicalTrials.gov/show/NCT01874587 Active, not recruiting Center Eugene Marquis 2020-10-31
NCT01810913 Radiation Therapy With Cisplatin, Docetaxel, or Cetuximab After Surgery in Treating Patients With Stage III-IV Squamous Cell Head and Neck Cancer https://ClinicalTrials.gov/show/NCT01810913 Active, not recruiting National Cancer Institute (NCI) 2027-01-01
NCT01806675 18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy https://ClinicalTrials.gov/show/NCT01806675 Completed Stanford University 2016-12-07
NCT01733797 Trismus Trial of Therabite vs Wooden Spatula in Head and Neck Cancer Patients https://ClinicalTrials.gov/show/NCT01733797 Completed The Christie NHS Foundation Trust 2015-08-31
NCT01711541 Combination Chemotherapy With or Without Veliparib in Treating Patients With Stage IV Head and Neck Cancer https://ClinicalTrials.gov/show/NCT01711541 Active, not recruiting National Cancer Institute (NCI) 2018-02-15
NCT01706939 The Quarterback Trial: Reduced Dose Radiotherapy for HPV+ Oropharynx Cancer https://ClinicalTrials.gov/show/NCT01706939 Active, not recruiting Icahn School of Medicine at Mount Sinai 2021-12-31
NCT01695122 Valproic Acid and Platinum-based Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma https://ClinicalTrials.gov/show/NCT01695122 Completed Instituto do Cancer do Estado de São Paulo 2014-11-30
NCT01663259 Reduced-intensity Therapy for Oropharyngeal Cancer in Non-smoking HPV-16 Positive Patients https://ClinicalTrials.gov/show/NCT01663259 Completed University of Michigan Rogel Cancer Center 2019-09-30
NCT01637194 Cetuximab and Everolimus in Treating Patients With Metastatic or Recurrent Colon Cancer or Head and Neck Cancer https://ClinicalTrials.gov/show/NCT01637194 Completed Fox Chase Cancer Center 2011-07-31
NCT01590355 A Phase II Randomized Trial for Early-stage Squamous Cell Carcinoma of the Oropharynx: Radiotherapy vs Trans-oral Robotic Surgery (ORATOR) https://ClinicalTrials.gov/show/NCT01590355 Active, not recruiting Lawson Health Research Institute 2021-06-30
NCT01585428 Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Human Papillomavirus-Associated Cancers https://ClinicalTrials.gov/show/NCT01585428 Completed National Institutes of Health Clinical Center (CC) 2016-04-09
NCT01530997 De-intensification of Radiation & Chemotherapy in Low-Risk Human Papillomavirus-related Oropharyngeal Squamous Cell Ca https://ClinicalTrials.gov/show/NCT01530997 Active, not recruiting UNC Lineberger Comprehensive Cancer Center 2014-11-30
NCT01504932 Freeze-Dried Black Raspberries in Preventing Oral Cancer Recurrence in High At-Risk Appalachian Patients Oral Cancer Survivors https://ClinicalTrials.gov/show/NCT01504932 Completed Ohio State University Comprehensive Cancer Center 2015-04-22
NCT01469429 Phase 1b Food Based Modulation of Biomarkers in Human Tissues at High-Risk for Oral Cancer. https://ClinicalTrials.gov/show/NCT01469429 Completed Ohio State University Comprehensive Cancer Center 2014-09-17
NCT01440270 Neo-adjuvant Erbitux-based Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer https://ClinicalTrials.gov/show/NCT01440270 Completed Shanghai Jiao Tong University School of Medicine 2014-10-31
NCT01435252 A Phase II Study In Patients With Advanced Head And Neck Cancer Of Standard Chemoradiation And Add-On Cetuximab https://ClinicalTrials.gov/show/NCT01435252 Completed University of Zurich 2017-10-25
NCT01434394 Neoadjuvant Erbitux Based Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer https://ClinicalTrials.gov/show/NCT01434394 Completed Shanghai Jiao Tong University School of Medicine 2014-10-31
NCT01365169 Post-op Wellness Program for Pancreatic Cancer Patients That Uses Patient Feedback and Real-time Provider Monitoring https://ClinicalTrials.gov/show/NCT01365169 Recruiting M.D. Anderson Cancer Center 2025-02-25
NCT01334177 TLR8 Agonist VTX-2337 and Cetuximab in Treating Patients With Locally Advanced, Recurrent, or Metastatic Squamous Cell Cancer of Head and Neck https://ClinicalTrials.gov/show/NCT01334177 Completed University of Washington 2014-06-30
NCT04287868 Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies https://ClinicalTrials.gov/show/NCT04287868 Recruiting National Institutes of Health Clinical Center (CC) 2021-07-30
NCT04277858 Neoadjuvant Chemotherapy and Transoral Robotic Surgery for Oropharyngeal Cancer. https://ClinicalTrials.gov/show/NCT04277858 Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre 2023-08-31
NCT04178174 Stereotactic Boost and Short-course Radiation Therapy for Oropharynx Cancer https://ClinicalTrials.gov/show/NCT04178174 Recruiting Centre hospitalier de l’Université de Montréal (CHUM) 2023-12-31
NCT04124198 Quality of Life After Primary TORS vs IMRT for Patients With Early-stage Oropharyngeal Squamous Cell Carcinoma https://ClinicalTrials.gov/show/NCT04124198 Recruiting Rigshospitalet, Denmark 2024-01-31
NCT04116047 CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC) https://ClinicalTrials.gov/show/NCT04116047 Recruiting University of Birmingham 2023-01-31
NCT04112940 Physiological Flow of Liquids in Head and Neck Cancer Patients: A Pilot Study https://ClinicalTrials.gov/show/NCT04112940 Active, not recruiting University Health Network, Toronto 2019-12-31
NCT04106362 Radiation Therapy and Cisplatin With or Without Cetuximab in Treating Patients With HPV Positive, KRAS-Variant Stage III-IV Oropharyngeal Squamous Cell Carcinoma https://ClinicalTrials.gov/show/NCT04106362 Recruiting Jonsson Comprehensive Cancer Center 2021-07-01
NCT04085120 Ropivacaine/Dexamethasone and 10% Lignocaine Injection in GPN Block for Intractable Cancer Pain https://ClinicalTrials.gov/show/NCT04085120 Recruiting All India Institute of Medical Sciences, New Delhi 2020-01-31
NCT04019548 Assessment of Swallowing Function and Quality of Life in Oropharyngeal Cancer Patients Treated by Chemo-radiotherapy https://ClinicalTrials.gov/show/NCT04019548 Recruiting Jules Bordet Institute 2023-04-01
NCT04012502 De-escalation Protocols in HPV-related Oropharyngeal Carcinoma in Chinese Populations https://ClinicalTrials.gov/show/NCT04012502 Recruiting Fudan University 2019-07-01
NCT04001413 Therapy for High-Risk HPV 16-Positive Oropharynx Cancer Patients https://ClinicalTrials.gov/show/NCT04001413 Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 2024-09-30
NCT03838263 Feasibility and Tolerance of Nivolumab Neoadjuvant Immunotherapy in High Risk HPV Driven Oropharynx Cancer https://ClinicalTrials.gov/show/NCT03838263 Recruiting UNICANCER 2020-12-31
NCT03799445 Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma https://ClinicalTrials.gov/show/NCT03799445 Recruiting M.D. Anderson Cancer Center 2022-08-01
NCT03735745 Transdisciplinary Oral/Oropharyngeal Cancer Research & Care in Head and Neck Cancer (TORCH) https://ClinicalTrials.gov/show/NCT03735745 Recruiting Medical University of South Carolina 2020-12-30
NCT03729518 TORS De-Intensification Protocol Version 2.0: Dose and Volume Reduction in the Neck https://ClinicalTrials.gov/show/NCT03729518 Recruiting Abramson Cancer Center of the University of Pennsylvania 2022-10-11
NCT03715946 Adjuvant De-Escalated Radiation + Adjuvant Nivolumab for Intermediate-High Risk P16+ Oropharynx Cancer https://ClinicalTrials.gov/show/NCT03715946 Recruiting University of Pittsburgh 2021-05-31
NCT03713021 TraceIT Tissue Marker to Mark the Primary Resection Bed Margins of Oropharyngeal Cancers https://ClinicalTrials.gov/show/NCT03713021 Recruiting Washington University School of Medicine 2021-05-31
NCT03691441 Comparative Effectiveness Trial of Transoral Head and Neck Surgery Followed by Adjuvant Radio(Chemo)Therapy Versus Primary Radiochemotherapy for Oropharyngeal Cancer https://ClinicalTrials.gov/show/NCT03691441 Recruiting Universitätsklinikum Hamburg-Eppendorf 2023-06-05
NCT03656133 Use of a Proliferation Saturation Index to Determine Personalized Radiotherapy for HPV + Oropharyngeal Cancers https://ClinicalTrials.gov/show/NCT03656133 Recruiting H. Lee Moffitt Cancer Center and Research Institute 2021-08-30
NCT03618134 Stereotactic Body Radiation Therapy and Durvalumab With or Without Tremelimumab Before Surgery in Treating Participants With Human Papillomavirus Positive Oropharyngeal Squamous Cell Caner https://ClinicalTrials.gov/show/NCT03618134 Recruiting Jonsson Comprehensive Cancer Center 2022-10-01
NCT03604588 Evaluation of HPV OncoTect â„¢ for the Etiological Diagnosis of HPV-induced Oropharyngeal Cancers https://ClinicalTrials.gov/show/NCT03604588 Recruiting Gustave Roussy, Cancer Campus, Grand Paris 2019-01-31
NCT03435471 Outcomes of Prophylactic Swallowing Therapy in Patients Undergoing Definitive Chemoradiation for Head and Neck Cancer https://ClinicalTrials.gov/show/NCT03435471 Active, not recruiting University of Miami 2020-08-31
NCT03427411 M7824 in Subjects With HPV Associated Malignancies https://ClinicalTrials.gov/show/NCT03427411 Recruiting National Institutes of Health Clinical Center (CC) 2021-12-31
NCT03422536 Ficlatuzumab w/wo Cetuximab in Patients w/Cetuximab-Resistant, Recurrent or Metastatic Head/Neck Squamous Cell Carcinoma https://ClinicalTrials.gov/show/NCT03422536 Recruiting University of Arizona 2020-12-31
NCT03416153 Individualized Adaptive De-escalated Radiotherapy for HPV-related Oropharynx Cancer https://ClinicalTrials.gov/show/NCT03416153 Recruiting University of Michigan Rogel Cancer Center 2021-11-21
NCT01173692 Minocycline for Reduction of Radiation Therapy Treatment-Related Symptom Burden in Oropharynx Cancer: A Randomized Study. https://ClinicalTrials.gov/show/NCT01173692 Active, not recruiting M.D. Anderson Cancer Center 2020-07-01
NCT01155609 L-lysine in Treating Oral Mucositis in Patients Undergoing Radiation Therapy With or Without Chemotherapy For Head and Neck Cancer https://ClinicalTrials.gov/show/NCT01155609 Completed University of Washington 2011-12-31
NCT01108042 TPF-Induction Chemotherapy of Oropharyngeal and Cavity of the Mouth Cancer https://ClinicalTrials.gov/show/NCT01108042 Completed University of Jena 2016-01-31
NCT01064921 Ph I Vorinostat in the Treatment of Advanced Staged Oropharyngeal Squamous Cell Carcinoma https://ClinicalTrials.gov/show/NCT01064921 Completed Ohio State University Comprehensive Cancer Center 2017-11-08
NCT01044433 Capecitabine and Lapatinib Ditosylate in Treating Patients With Squamous Cell Cancer of the Head and Neck https://ClinicalTrials.gov/show/NCT01044433 Completed Abramson Cancer Center of the University of Pennsylvania 2015-09-24
NCT01032928 Respiratory-Swallow Training in Veterans With Oropharyngeal Cancer https://ClinicalTrials.gov/show/NCT01032928 Completed VA Office of Research and Development 2013-07-31
NCT00939627 Phase II Randomized Trial of the Combination of Cetuximab and Sorafenib or Single Agent Cetuximab https://ClinicalTrials.gov/show/NCT00939627 Completed National Cancer Institute (NCI) 2013-01-31
NCT03418792 Functional Sparing of Salivary Glands Using MRI Sialography for Patients Undergoing Definitive Radiation Therapy for Head and Neck Cancers of the Oropharynx https://ClinicalTrials.gov/show/NCT03418792 Active, not recruiting UNC Lineberger Comprehensive Cancer Center 2021-03-31
NCT04162873 Celecoxib Through Surgery and Radiation Therapy for the Treatment of Advanced Head and Neck Cancer https://ClinicalTrials.gov/show/NCT04162873 Recruiting University of Utah 2024-10-12
NCT02953197 18F-FDG-PET Guided Dose-Painting With Intensity Modulated Radiotherapy in Oropharyngeal Tumours https://ClinicalTrials.gov/show/NCT02953197 Completed Guy’s and St Thomas’ NHS Foundation Trust 2018-01-31
NCT03952585 De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer https://ClinicalTrials.gov/show/NCT03952585 Recruiting National Cancer Institute (NCI) 2025-02-28
NCT03811015 Testing Maintenance Immunotherapy Versus Observation in Patients With Oropharynx Cancer https://ClinicalTrials.gov/show/NCT03811015 Recruiting National Cancer Institute (NCI) 2027-01-01
NCT03423264 PROGRESS Trial - Prophylactic Gabapentin for Relief of Symptoms and Improved Swallowing https://ClinicalTrials.gov/show/NCT03423264 Recruiting University of Chicago 2020-06-01
NCT00780312 Physiotherapy Treatment for Patients Suffering From Head and Neck Cancer https://ClinicalTrials.gov/show/NCT00780312 Completed Rigshospitalet, Denmark 2012-03-31
NCT00721799 F-18 Fluorothymidine PET Imaging for Early Evaluation of Response to Therapy in Head & Neck Cancer Patients https://ClinicalTrials.gov/show/NCT00721799 Completed University of Iowa 2014-12-31
NCT00492089 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer https://ClinicalTrials.gov/show/NCT00492089 Completed National Cancer Institute (NCI) 2010-08-31
NCT00513435 Saracatinib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer https://ClinicalTrials.gov/show/NCT00513435 Completed National Cancer Institute (NCI) 2011-03-31
NCT00507767 Dasatinib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer https://ClinicalTrials.gov/show/NCT00507767 Completed National Cancer Institute (NCI) 2010-02-28
NCT00490282 A Pilot Trial of Image-Guided Adaptive Radiotherapy for Head and Neck Cancer https://ClinicalTrials.gov/show/NCT00490282 Completed M.D. Anderson Cancer Center 2015-05-31
NCT00486304 Low Antioxidant Diet in Controlling Cachexia in Patients With Oropharyngeal Cancer Receiving Chemotherapy and Radiation Therapy https://ClinicalTrials.gov/show/NCT00486304 Completed UNC Lineberger Comprehensive Cancer Center 2007-02-28
NCT00473564 Robotic Assisted Surgery in Upper Aerodigestive Tract Surgery https://ClinicalTrials.gov/show/NCT00473564 Completed University of Alabama at Birmingham 2013-12-31
NCT00470496 Photodynamic Therapy Using HPPH in Treating Patients Undergoing Surgery for Primary or Recurrent Head and Neck Cancer https://ClinicalTrials.gov/show/NCT00470496 Completed Roswell Park Cancer Institute 2011-10-28
NCT00410826 Cisplatin and Radiation Therapy With or Without Erlotinib Hydrochloride in Treating Patients With Stage III or Stage IV Head and Neck Cancer https://ClinicalTrials.gov/show/NCT00410826 Completed University of Washington 2012-05-31
NCT00397384 Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer https://ClinicalTrials.gov/show/NCT00397384 Completed National Cancer Institute (NCI) 2013-06-30
NCT00387335 Sunitinib in Treating Patients With Recurrent and/or Metastatic Head and Neck Cancer https://ClinicalTrials.gov/show/NCT00387335 Completed National Cancer Institute (NCI) 2010-03-31
NCT00330382 Bowman-Birk Inhibitor Concentrate in Preventing Cancer in Patients With Oral Leukoplakia https://ClinicalTrials.gov/show/NCT00330382 Completed National Cancer Institute (NCI) 2010-07-31
NCT00162708 Very Intense Radiotherapy-Chemotherapy Regimen in Advanced HNSCC https://ClinicalTrials.gov/show/NCT00162708 Completed Gustave Roussy, Cancer Campus, Grand Paris NA
NCT00158678 IMRT Plus Cisplatin Versus Conventional Radiotherapy Plus Cisplatin in Stage III-IV HNSCC https://ClinicalTrials.gov/show/NCT00158678 Completed Groupe Oncologie Radiotherapie Tete et Cou 2020-03-22
NCT00158652 Accelerated Radiotherapy and Concomitant Chemo-radiotherapy in HNSCC https://ClinicalTrials.gov/show/NCT00158652 Completed Groupe Oncologie Radiotherapie Tete et Cou 2011-03-31
NCT00114283 Lapatinib Ditosylate in Treating Patients With Metastatic or Recurrent Head and Neck Cancer https://ClinicalTrials.gov/show/NCT00114283 Completed National Cancer Institute (NCI) 2006-10-31
NCT00103259 Bortezomib With or Without Irinotecan in Treating Patients With Locally Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck https://ClinicalTrials.gov/show/NCT00103259 Completed National Cancer Institute (NCI) 2011-11-30
NCT00101348 Erlotinib and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic or Unresectable Kidney, Colorectal, Head and Neck, Pancreatic, or Non-Small Cell Lung Cancer https://ClinicalTrials.gov/show/NCT00101348 Completed National Cancer Institute (NCI) 2007-10-31
NCT00098631 Lapatinib in Treating Patients With Recurrent and/or Metastatic Head and Neck Cancer https://ClinicalTrials.gov/show/NCT00098631 Completed National Cancer Institute (NCI) 2006-12-31
NCT00096512 S0420, Sorafenib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer https://ClinicalTrials.gov/show/NCT00096512 Completed National Cancer Institute (NCI) 2006-05-31
NCT00095628 SB-715992 in Treating Patients With Recurrent or Metastatic Head and Neck Cancer https://ClinicalTrials.gov/show/NCT00095628 Completed National Cancer Institute (NCI) 2010-07-31
NCT00089362 Alvespimycin Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors https://ClinicalTrials.gov/show/NCT00089362 Completed National Cancer Institute (NCI) 2008-01-31
NCT00004074 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu https://ClinicalTrials.gov/show/NCT00004074 Completed National Cancer Institute (NCI) 2009-02-28
NCT00068497 Gefitinib in Treating Patients With Metastatic or Unresectable Head and Neck Cancer or Non-Small Cell Lung Cancer https://ClinicalTrials.gov/show/NCT00068497 Completed National Cancer Institute (NCI) 2007-12-31
NCT00064103 Gene Therapy in Preventing Cancer in Patients With Premalignant Carcinoma of the Oral Cavity or Pharynx https://ClinicalTrials.gov/show/NCT00064103 Completed National Cancer Institute (NCI) 2007-08-31
NCT00063895 Erlotinib in Treating Patients With Advanced Non-Small Cell Lung Cancer, Ovarian Cancer, or Squamous Cell Carcinoma of the Head and Neck https://ClinicalTrials.gov/show/NCT00063895 Completed National Cancer Institute (NCI) 2005-10-31
NCT00055913 Bevacizumab and Erlotinib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer https://ClinicalTrials.gov/show/NCT00055913 Completed National Cancer Institute (NCI) 2007-09-30
NCT00055770 Erlotinib Plus Docetaxel in Treating Patients With Locally Advanced, Metastatic, or Recurrent Head and Neck Cancer https://ClinicalTrials.gov/show/NCT00055770 Completed National Cancer Institute (NCI) 2006-12-31
NCT00049283 Erlotinib, Docetaxel, and Radiation Therapy in Treating Patients With Locally Advanced Head and Neck Cancer https://ClinicalTrials.gov/show/NCT00049283 Completed National Cancer Institute (NCI) 2008-02-29
NCT00049166 Erlotinib and Radiation Therapy With or Without Cisplatin in Treating Patients With Mouth or Throat Cancer https://ClinicalTrials.gov/show/NCT00049166 Completed National Cancer Institute (NCI) 2007-07-31
NCT00033618 Ixabepilone in Treating Patients With Metastatic or Recurrent Squamous Cell Cancer of the Head and Neck https://ClinicalTrials.gov/show/NCT00033618 Completed National Cancer Institute (NCI) 2007-01-31
NCT00031681 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) https://ClinicalTrials.gov/show/NCT00031681 Completed National Cancer Institute (NCI) 2011-01-31
NCT00030498 Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction https://ClinicalTrials.gov/show/NCT00030498 Completed National Cancer Institute (NCI) 2007-07-31
NCT00023959 Bevacizumab, Fluorouracil, and Hydroxyurea Plus Radiation Therapy in Treating Patients With Advanced Head and Neck Cancer https://ClinicalTrials.gov/show/NCT00023959 Completed National Cancer Institute (NCI) 2010-03-31
NCT00006360 Radiation Therapy in Treating Patients With Stage II or Stage III Oropharyngeal Cancer https://ClinicalTrials.gov/show/NCT00006360 Completed Radiation Therapy Oncology Group 2005-11-30

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03239834 Clinical Evaluation of the OncAlert RAPID in Subjects Presenting for Evaluation and/or Initial Biopsy; Impact on Decision-Making https://ClinicalTrials.gov/show/NCT03239834 Recruiting Vigilant Biosciences, Inc. 2020-03-31
NCT03175770 Feasibility of Radiofrequency Resection in Oropharyngeal Tumor Surgery https://ClinicalTrials.gov/show/NCT03175770 Completed Technische Universität München 2017-06-01
NCT03010150 Blood Tests and Questionnaires in Studying Adherence to Preventative Swallowing Exercises in Participants With Metastatic Head and Neck Cancer https://ClinicalTrials.gov/show/NCT03010150 Recruiting M.D. Anderson Cancer Center 2019-12-31
NCT02934724 Impact of HPV Vaccine On The Prevalence Of HPV In Norway https://ClinicalTrials.gov/show/NCT02934724 Completed Oslo University Hospital 2017-02-28
NCT02736786 A Study of Mucosal Sparing Proton Beam Therapy (PBT) in Resected Oropharyngeal Tumors https://ClinicalTrials.gov/show/NCT02736786 Active, not recruiting Mayo Clinic 2021-03-31
NCT02365844 Multispectral Imaging to Characterize Patterns of Vascular Supply Within Lymphoepithelial Mucosa in Oropharyngeal Cancer https://ClinicalTrials.gov/show/NCT02365844 Completed Stanford University 2018-08-27
NCT02262247 A Post-Market Clinical Trial for Access and Visualization of the Oropharynx, Hypopharynx and Larynx During Transoral Procedures https://ClinicalTrials.gov/show/NCT02262247 Completed Medrobotics Corporation 2015-12-31
NCT02245100 Circulating Tumor DNA in Predicting Outcomes in Patients With Stage IV Head and Neck Cancer or Stage III-IV Non-small Cell Lung Cancer https://ClinicalTrials.gov/show/NCT02245100 Recruiting Thomas Jefferson University 2020-07-31
NCT02147418 Exosome Testing as a Screening Modality for Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma https://ClinicalTrials.gov/show/NCT02147418 Recruiting New Mexico Cancer Care Alliance 2021-01-31
NCT01358097 Role of Immune Activation in Response of Head and Neck Squamous Cell Carcinoma to Therapy https://ClinicalTrials.gov/show/NCT01358097 Completed Icahn School of Medicine at Mount Sinai 2013-09-30
NCT01342978 Human Papillomavirus (HPV) Oral Transmission Study in Partners Over Time https://ClinicalTrials.gov/show/NCT01342978 Completed Johns Hopkins Bloomberg School of Public Health 2014-12-31
NCT04266093 Gene Therapy Follow up for Subjects Previously Enrolled in NCI Genitourinary Malignancies Branch or Experimental Transplantation and Immunology Branch Studies https://ClinicalTrials.gov/show/NCT04266093 Enrolling by invitation National Institutes of Health Clinical Center (CC) 2035-10-01
NCT04189003 Molecular Signatures of HPV+ ORL Cancers (OROPAP) https://ClinicalTrials.gov/show/NCT04189003 Active, not recruiting Assistance Publique - Hôpitaux de Paris 2020-11-30
NCT03890783 Functional Results of Soft Palate Free Flap Reconstruction https://ClinicalTrials.gov/show/NCT03890783 Recruiting Hospices Civils de Lyon 2020-08-27
NCT03777384 EValuating the Safety Of De-escaLated Head and Neck Irradiation in HPV positivE Oropharynx Cancer in Non-smokers/Minimal Smokers https://ClinicalTrials.gov/show/NCT03777384 Recruiting Sanford Health 2020-07-31
NCT03555721 CytID Analysis of Oral Lesions https://ClinicalTrials.gov/show/NCT03555721 Recruiting The University of Texas Health Science Center, Houston 2019-11-01
NCT03418909 Functional Outcome After Treatment for Oropharyngeal Squamous Cell Carcinoma https://ClinicalTrials.gov/show/NCT03418909 Active, not recruiting Rigshospitalet, Denmark 2020-03-31
NCT01104714 Pharmacogenetic Response to Chemotherapy Induction for ORL Cancers https://ClinicalTrials.gov/show/NCT01104714 Completed Centre Hospitalier Universitaire de Nīmes 2014-07-31
NCT01084733 Nicotine Levels With Response Rates to Radiation Alone or With Chemo In Head & Neck Cancer https://ClinicalTrials.gov/show/NCT01084733 Active, not recruiting University of Kentucky 2021-02-28
NCT00662662 Sexual Behavior in Head and Neck Cancer Patients https://ClinicalTrials.gov/show/NCT00662662 Active, not recruiting M.D. Anderson Cancer Center 2022-05-31
NCT00508170 Sexual Behavior in Oropharyngeal Patients Versus Head and Neck Cancer Patients, With or Without HPV Infection https://ClinicalTrials.gov/show/NCT00508170 Completed M.D. Anderson Cancer Center 2010-01-31
NCT00498875 Depression and Adherence in Head and Neck Cancer https://ClinicalTrials.gov/show/NCT00498875 Active, not recruiting M.D. Anderson Cancer Center 2020-12-31

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT02012699 Integrated Cancer Repository for Cancer Research https://ClinicalTrials.gov/show/NCT02012699 Recruiting University of Nebraska 2099-12-31
NCT03644563 Men and Women Offering Understanding of Throat HPV https://ClinicalTrials.gov/show/NCT03644563 Recruiting Johns Hopkins Bloomberg School of Public Health 2024-04-30